Binding and transport of SFPQ-RNA granules by KIF5A/KLC1 motors promotes axon survival

Complex neural circuitry requires stable connections formed by lengthy axons. To maintain these functional circuits, fast transport delivers RNAs to distal axons where they undergo local translation. However, the mechanism that enables long-distance transport of RNA granules is not yet understood. H...

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Publicado no:J Cell Biol
Main Authors: Fukuda, Yusuke, Pazyra-Murphy, Maria F., Silagi, Elizabeth S., Tasdemir-Yilmaz, Ozge E., Li, Yihang, Rose, Lillian, Yeoh, Zoe C., Vangos, Nicholas E., Geffken, Ezekiel A., Seo, Hyuk-Soo, Adelmant, Guillaume, Bird, Gregory H., Walensky, Loren D., Marto, Jarrod A., Dhe-Paganon, Sirano, Segal, Rosalind A.
Formato: Artigo
Idioma:Inglês
Publicado em: Rockefeller University Press 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7721913/
https://ncbi.nlm.nih.gov/pubmed/33284322
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.202005051
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