Regulation of the Fasciola hepatica newly excysted juvenile cathepsin L3 (FhCL3) by its propeptide: a proposed ‘clamp-like’ mechanism of binding and inhibition

BACKGROUND: The zoonotic worm parasite Fasciola hepatica secretes an abundance of cathepsin L peptidases that are associated with virulence, invasiveness, feeding and migration. The peptidases are produced as inactive zymogens that activate at low pH by autocatalytic removal of their N-terminal pro-...

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Veröffentlicht in:BMC Mol Cell Biol
Hauptverfasser: Pritsch, Izanara C., Tikhonova, Irina G., Jewhurst, Heather L., Drysdale, Orla, Cwiklinski, Krystyna, Molento, Marcelo B., Dalton, John P., Verissimo, Carolina De M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2020
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7720491/
https://ncbi.nlm.nih.gov/pubmed/33287692
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12860-020-00335-5
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