Thymus-derived B cell clones persist in the circulation after thymectomy in myasthenia gravis

Myasthenia gravis (MG) is a neuromuscular, autoimmune disease caused by autoantibodies that target postsynaptic proteins, primarily the acetylcholine receptor (AChR) and inhibit signaling at the neuromuscular junction. The majority of patients under 50 y with AChR autoantibody MG have thymic lymphof...

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Gepubliceerd in:Proc Natl Acad Sci U S A
Hoofdauteurs: Jiang, Ruoyi, Hoehn, Kenneth B., Lee, Casey S., Pham, Minh C., Homer, Robert J., Detterbeck, Frank C., Aban, Inmaculada, Jacobson, Leslie, Vincent, Angela, Nowak, Richard J., Kaminski, Henry J., Kleinstein, Steven H., O’Connor, Kevin C.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: National Academy of Sciences 2020
Onderwerpen:
Biological Sciences
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7720237/
https://ncbi.nlm.nih.gov/pubmed/33199596
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2007206117
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