The Combination of CD8αα and Peptide-MHC-I in a Face-to-Face Mode Promotes Chicken γδT Cells Response

The CD8αα homodimer is crucial to both thymic T cell selection and the antigen recognition of cytotoxic T cells. The CD8-pMHC-I interaction can enhance CTL immunity via stabilizing the TCR-pMHC-I interaction and optimizing the cross-reactivity and Ag sensitivity of CD8(+) T cells at various stages o...

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Foilsithe in:Front Immunol
Main Authors: Liu, Yanjie, Chen, Rong, Liang, Ruiying, Sun, Beibei, Wu, Yanan, Zhang, Lijie, Kaufman, Jim, Xia, Chun
Formáid: Artigo
Teanga:Inglês
Foilsithe: Frontiers Media S.A. 2020
Ábhair:
Immunology
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7719794/
https://ncbi.nlm.nih.gov/pubmed/33329601
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2020.605085
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