Which Factors Affect the Occurrence of Off-Target Effects Caused by the Use of CRISPR/Cas: A Systematic Review in Plants

CRISPR/Cas enables a targeted modification of DNA sequences. Despite their ease and efficient use, one limitation is the potential occurrence of associated off-target effects. This systematic review aims to answer the following research question: Which factors affect the occurrence of off-target eff...

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Detalles Bibliográficos
Publicado en:Front Plant Sci
Autores principales: Modrzejewski, Dominik, Hartung, Frank, Lehnert, Heike, Sprink, Thorben, Kohl, Christian, Keilwagen, Jens, Wilhelm, Ralf
Formato: Artigo
Lenguaje:Inglês
Publicado: Frontiers Media S.A. 2020
Materias:
Plant Science
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7719684/
https://ncbi.nlm.nih.gov/pubmed/33329634
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fpls.2020.574959
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