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Close-up: HIV/SIV intasome structures shed new light on integrase inhibitor binding and viral escape mechanisms
Integrase strand transfer inhibitors (INSTIs) are important components of drug formulations that are used to treat people living with HIV, and second-generation INSTIs dolutegravir and bictegravir impart high barriers to the development of drug resistance. Reported 10 years ago, X-ray crystal struct...
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| Published in: | FEBS J |
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| Main Authors: | , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
2020
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7719574/ https://ncbi.nlm.nih.gov/pubmed/32506843 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/febs.15438 |
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