Safety, Pharmacokinetics, and Pharmacodynamics of TD‐0714, a Novel Potent Neprilysin Inhibitor in Healthy Adult and Elderly Subjects

TD‐0714 is an orally active, potent, and selective inhibitor of human neprilysin (NEP) in development for the treatment of chronic heart failure. Oral administration of TD‐0714 in rats resulted in dose‐dependent and sustained increases in plasma cyclic guanosine monophosphate (cGMP) over 24 hours co...

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Vydáno v:Clin Transl Sci
Hlavní autoři: Kanodia, Jitendra, Lo, Arthur, Baldwin, R. Michael, Colley, Ken, Zhou, Kefei, Bourdet, David L.
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2020
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7719375/
https://ncbi.nlm.nih.gov/pubmed/32506827
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cts.12831
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