Monoclonal Antibodies Counteract Opioid-Induced Behavioral and Toxic Effects in Mice and Rats

Monoclonal antibodies (mAbs) and vaccines have been proposed as medical countermeasures to treat opioid use disorder (OUD) and prevent opioid overdose. In contrast to current pharmacotherapies (e.g., methadone, buprenorphine, naltrexone, and naloxone) for OUD and overdose, which target brain opioid...

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Vydáno v:J Pharmacol Exp Ther
Hlavní autoři: Baehr, Carly, Kelcher, April Huseby, Khaimraj, Aaron, Reed, Dana E., Pandit, Sujata G., AuCoin, David, Averick, Saadyah, Pravetoni, Marco
Médium: Artigo
Jazyk:Inglês
Vydáno: The American Society for Pharmacology and Experimental Therapeutics 2020
Témata:
Drug Discovery and Translational Medicine
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7718726/
https://ncbi.nlm.nih.gov/pubmed/32980813
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.120.000124
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