Novel [(N-alkyl-3-indolylmethylene)hydrazono]oxindoles arrest cell cycle and induce cell apoptosis by inhibiting CDK2 and Bcl-2: synthesis, biological evaluation and in silico studies

As a continuation for our previous work, a novel set of N-alkylindole-isatin conjugates (7, 8a–c, 9 and 10a–e) is here designed and synthesised with the prime aim to develop more efficient isatin-based antitumor candidates. Utilising the SAR outputs from the previous study, our design here is based...

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Detalhes bibliográficos
Publicado no:J Enzyme Inhib Med Chem
Main Authors: Al-Warhi, Tarfah, Abo-Ashour, Mahmoud F., Almahli, Hadia, Alotaibi, Ohoud J., Al-Sanea, Mohammad M., Al-Ansary, Ghada H., Ahmed, Hanaa Y., Elaasser, Mahmoud M., Eldehna, Wagdy M., Abdel-Aziz, Hatem A.
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2020
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7717600/
https://ncbi.nlm.nih.gov/pubmed/32522063
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/14756366.2020.1773814
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