Female human primordial germ cells display X-chromosome dosage compensation despite the absence of X-inactivation

X-chromosome dosage compensation in female placental mammals is achieved by X-chromosome inactivation (XCI). An exception are human pre-implantation embryos, where dosage compensation occurs by X-chromosome dampening (XCD). Here, we examined whether XCD extends to human prenatal germ cells given the...

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Udgivet i:Nat Cell Biol
Main Authors: Chitiashvili, Tsotne, Dror, Iris, Kim, Rachel, Hsu, Fei-Man, Chaudhari, Rohan, Pandolfi, Erica, Chen, Di, Liebscher, Simone, Schenke-Layland, Katja, Plath, Kathrin, Clark, Amander
Format: Artigo
Sprog:Inglês
Udgivet: 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7717582/
https://ncbi.nlm.nih.gov/pubmed/33257808
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41556-020-00607-4
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