Platelet-derived calpain cleaves the endothelial protease-activated receptor 1 to induce vascular inflammation in diabetes

Diabetes mellitus is a major risk factor for cardiovascular disease. Platelets from diabetic patients are hyperreactive and release microparticles that carry activated cysteine proteases or calpains. Whether platelet-derived calpains contribute to the development of vascular complications in diabete...

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Bibliografske podrobnosti
izdano v:Basic Res Cardiol
Main Authors: Kyselova, Anastasia, Elgheznawy, Amro, Wittig, Ilka, Heidler, Juliana, Mann, Alexander W., Ruf, Wolfram, Fleming, Ingrid, Randriamboavonjy, Voahanginirina
Format: Artigo
Jezik:Inglês
Izdano: Springer Berlin Heidelberg 2020
Teme:
Original Contribution
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7716944/
https://ncbi.nlm.nih.gov/pubmed/33258989
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00395-020-00833-9
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