Cisplatin and carboplatin result in similar gonadotoxicity in immature human testis with implications for fertility preservation in childhood cancer

BACKGROUND: Clinical studies indicate chemotherapy agents used in childhood cancer treatment regimens may impact future fertility. However, effects of individual agents on prepubertal human testis, necessary to identify later risk, have not been determined. The study aimed to investigate the impact...

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Detalhes bibliográficos
Publicado no:BMC Med
Main Authors: Tharmalingam, Melissa D., Matilionyte, Gabriele, Wallace, William H. B., Stukenborg, Jan-Bernd, Jahnukainen, Kirsi, Oliver, Elizabeth, Goriely, Anne, Lane, Sheila, Guo, Jingtao, Cairns, Bradley, Jorgensen, Anne, Allen, Caroline M., Lopes, Federica, Anderson, Richard A., Spears, Norah, Mitchell, Rod T.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7716476/
https://ncbi.nlm.nih.gov/pubmed/33272271
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12916-020-01844-y
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