ATRT-25. INTEGRATED QUANTITATIVE SWATH-MS PROTEOMICS ANALYSIS OF ATRTs UNCOVERS NEW THERAPEUTIC OPPORTUNITIES

The consequences of SMARCB1 loss in Atypical Teratoid Rhabdoid Tumors (ATRTs) have been extensively characterized at the epigenetic/transcriptomic level. In this study we detail the functional effect of SMARCB1 mutation on the MRT proteome, its relationship with RNA deregulation or lack thereof. We...

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Bibliographische Detailangaben
Veröffentlicht in:Neuro Oncol
Hauptverfasser: Finetti, Martina Anna, Hacking, James, Lishman-Walker, Emma, Synowsky, Silvia A, Crosier, Stephen, Martin, Emmma, Burns, Jess, Shirran, Sally L, Bailey, Simon, Clifford, Steven C, Huang, Paul, Williamson, Daniel
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2020
Schlagworte:
Atypical Teratoid/Rhabdoid Tumors
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7715928/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa222.024
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