IMMU-10. INTERIM ANALYSIS OF THE HIT-HGG REZ IMMUNVAC STUDY - DENDRITIC CELL VACCINATION WITH PARTIAL TREG DEPLETION IN CHILDREN, ADOLESCENTS, AND ADULTS WITH RELAPSED HIGH-GRADE GLIOMAS

Efficacy of therapeutic dendritic cell vaccines (DCV) can be limited by immunosuppressive mechanisms in the micromilieu of high-grade gliomas. In the HIT-HGG-Rez Immunovac trial (Eudra-CT 2013-000419-26), we investigate whether a reduction of Treg with metronomic cyclophosphamide (metrCyc) might be...

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Bibliographic Details
Published in:Neuro Oncol
Main Authors: Eyrich, Matthias, Krauss, Jürgen, Rachor, Johannes, Monoranu, Camelia, Bison, Brigitte, Löhr, Mario, Rückriegel, Stefan, Wölfl, Matthias, Miller, Elisabeth, Schlegel, Paul G, Kramm, Christof
Format: Artigo
Language:Inglês
Published: Oxford University Press 2020
Subjects:
Immunotherapy
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7715918/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa222.366
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