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EPCT-07. DEBIO1347, AN ORAL FGFR INHIBITOR: RESULTS FROM A SINGLE CENTER STUDY IN RECURRENT/REFRACTORY FGFR ALTERED PEDIATRIC GLIOMAS

BACKGROUND: Oncogenic driver alterations in FGFR are present in a subset of pediatric gliomas. Debio1347 is an orally available, highly selective FGFR 1–3 inhibitor that had a favorable safety profile and encouraging preliminary clinical activity in an adult phase 1 study. METHODS: Five children wit...

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Bibliografiske detaljer
Udgivet i:Neuro Oncol
Main Authors: Sait, Sameer Farouk, Gilheeney, Stephen, Dunkel, Ira, Karajannis, Matthias
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2020
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7715803/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa222.131
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