NFB-01. FUNCTIONAL CHARACTERIZATION OF ATRX LOSS IN NF1-ASSOCIATED GLIOMA AND MPNST

To identify the biologic relevance of ATRX loss in NF1-associated gliomagenesis, we studied the effects of Atrx loss using four previously characterized Nf1(+/-)Trp53(+/-) murine glioma lines. Lines 130G#3 and 158D#8 (corresponding to grade IV and III gliomas, respectively) displayed preserved ATRX...

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Publicat a:Neuro Oncol
Autors principals: Yuan, Ming, Reilly, Karlyne, Pratilas, Christine, Heaphy, Christopher, Rodriguez, Fausto
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2020
Matèries:
Neurofibromatosis
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7715779/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa222.605
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