HGG-32. UNCOVERING THERAPEUTIC VULNERABILITIES IN MISMATCH REPAIR-DEFICIENT GLIOMAS

INTRODUCTION: We have observed that approximately 26% of recurrent gliomas acquire hypermutation following treatment with temozolomide (TMZ). Intriguingly, 91% of these tumors harbor mutations in mismatch repair (MMR) genes. Strategies to target MMR-deficient gliomas thus stand to impact a large num...

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Bibliographic Details
Published in:Neuro Oncol
Main Authors: Boynton, Adam, Pal, Sangita, Touat, Mehdi, Currimjee, Naomi, Qian, Kenin, Bellamy, Charlotte, Ho, Patricia, Berstler, Jim, Ligon, Keith, Beroukhim, Rameen, Bandopadhayay, Pratiti
Format: Artigo
Language:Inglês
Published: Oxford University Press 2020
Subjects:
High Grade Glioma
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7715373/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa222.314
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