EPCT-16. A PHASE IB STUDY OF PTC596 IN CHILDREN WITH NEWLY DIAGNOSED DIFFUSE INTRINSIC PONTINE GLIOMA AND HIGH GRADE GLIOMA

BACKGROUND: BMI-1 is highly expressed in DIPG. Downregulation leads to inhibition of cell proliferation, cell cycle signaling, self-renewal, telomerase expression, activity, and suppression of DIPG cell migration. Targeted inhibition of BMI-1 sensitizes DIPG cells to radiation and drug-induced DNA d...

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Vydáno v:Neuro Oncol
Hlavní autoři: Smiley, Natasha Pillay, Baxter, Patricia, Kumar, Shiva, Hwang, Eugene, Breneman, John, Lane, Adam, Doughman, Renee, Deutsch, Michelle, Stevenson, Charles, Stewart, Clinton, Leach, Jim, Li, Xiao-Nan, Romero, Sonia, Maliakal, Pius, Gao, Lan, Fouladi, Maryam, Drissi, Rachid
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2020
Témata:
Early Phase Clinical Trials
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7715251/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa222.138
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