Hydroxychloroquine prophylaxis and treatment is ineffective in macaque and hamster SARS-CoV-2 disease models

We remain largely without effective prophylactic/therapeutic interventions for COVID-19. Although many human COVID-19 clinical trials are ongoing, there remains a deficiency of supportive preclinical drug efficacy studies to help guide decisions. Here we assessed the prophylactic/therapeutic efficac...

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Udgivet i:JCI Insight
Main Authors: Rosenke, Kyle, Jarvis, Michael A., Feldmann, Friederike, Schwarz, Benjamin, Okumura, Atsushi, Lovaglio, Jamie, Saturday, Greg, Hanley, Patrick W., Meade-White, Kimberly, Williamson, Brandi N., Hansen, Frederick, Perez-Perez, Lizette, Leventhal, Shanna, Tang-Huau, Tsing-Lee, Callison, Julie, Haddock, Elaine, Stromberg, Kaitlin A., Scott, Dana, Sewell, Graham, Bosio, Catharine M., Hawman, David, de Wit, Emmie, Feldmann, Heinz
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2020
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7714406/
https://ncbi.nlm.nih.gov/pubmed/33090972
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.143174
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