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Autoclave treatment of the classical scrapie agent US No. 13-7 and experimental inoculation to susceptible VRQ/ARQ sheep via the oral route results in decreased transmission efficiency

Scrapie, a prion disease of sheep, is highly resistant to conventional deactivation. Numerous methods to deactivate scrapie have been tested in laboratory animal models, and adequate autoclave treatment can reduce or remove the infectivity of some classical scrapie strains depending on the heating p...

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Pubblicato in:PLoS One
Autori principali: Cassmann, Eric D., Mammadova, Najiba, Greenlee, Justin J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2020
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7714121/
https://ncbi.nlm.nih.gov/pubmed/33270721
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0243009
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