Reduced GABAergic Neuron Excitability, Altered Synaptic Connectivity, and Seizures in a KCNT1 Gain-of-Function Mouse Model of Childhood Epilepsy

Gain-of-function (GOF) variants in K(+) channels cause severe childhood epilepsies, but there are no mechanisms to explain how increased K(+) currents lead to network hyperexcitability. Here, we introduce a human Na(+)-activated K(+) (K(Na)) channel variant (KCNT1-Y796H) into mice and, using a multi...

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Udgivet i:Cell Rep
Main Authors: Shore, Amy N., Colombo, Sophie, Tobin, William F., Petri, Sabrina, Cullen, Erin R., Dominguez, Soledad, Bostick, Christopher D., Beaumont, Michael A., Williams, Damian, Khodagholy, Dion, Yang, Mu, Lutz, Cathleen M., Peng, Yueqing, Gelinas, Jennifer N., Goldstein, David B., Boland, Michael J., Frankel, Wayne N., Weston, Matthew C.
Format: Artigo
Sprog:Inglês
Udgivet: 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7712469/
https://ncbi.nlm.nih.gov/pubmed/33113364
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2020.108303
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