Pathogenic, glycolytic PD-1(+) B cells accumulate in the hypoxic RA joint

While autoantibodies are used in the diagnosis of rheumatoid arthritis (RA), the function of B cells in the inflamed joint remains elusive. Extensive flow cytometric characterization and SPICE algorithm analyses of single-cell synovial tissue from patients with RA revealed the accumulation of switch...

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Détails bibliographiques
Publié dans:JCI Insight
Auteurs principaux: Floudas, Achilleas, Neto, Nuno, Marzaioli, Viviana, Murray, Kieran, Moran, Barry, Monaghan, Michael G., Low, Candice, Mullan, Ronan H., Rao, Navin, Krishna, Vinod, Nagpal, Sunil, Veale, Douglas J., Fearon, Ursula
Format: Artigo
Langue:Inglês
Publié: American Society for Clinical Investigation 2020
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7710281/
https://ncbi.nlm.nih.gov/pubmed/33148884
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.139032
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