Increased Colonic Expression of ACE2 Associates with Poor Prognosis in Crohn’s disease

BACKGROUND AND AIMS: The host receptor for SARS-CoV-2, angiotensin-converting enzyme 2 (ACE2), is highly expressed in small intestine. Our aim was to study colonic ACE2 expression in Crohn’s disease (CD) and non-inflammatory bowel disease (non-IBD) controls. We hypothesized that the colonic expressi...

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Veröffentlicht in:bioRxiv
Hauptverfasser: Toyonaga, Takahiko, Araba, Kenza C., Kennedy, Meaghan M., Keith, Benjamin P., Wolber, Elisabeth A., Beasley, Caroline, Steinbach, Erin C., Schaner, Matthew R., Jain, Animesh, Long, Millie D., Barnes, Edward L., Herfarth, Hans H., Isaacs, Kim L., Hansen, Jonathan J., Kapadia, Muneera, Gaston Guillem, José, Koruda, Mark J., Rahbar, Reza, Sadiq, Tim, Gulati, Ajay S., Sethupathy, Praveen, Furey, Terrence S., Ehre, Camille, Sheikh, Shehzad Z.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Cold Spring Harbor Laboratory 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7709167/
https://ncbi.nlm.nih.gov/pubmed/33269348
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/2020.11.24.396382
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