Conformational maps of human 20S proteasomes reveal PA28- and immuno-dependent inter-ring crosstalks

Hydrogen-Deuterium eXchange coupled to Mass Spectrometry (HDX-MS) is now common practice in structural biology. However, it is most of the time applied to rather small oligomeric complexes. Here, we report on the use of HDX-MS to investigate conformational differences between the human standard 20S...

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Veröffentlicht in:Nat Commun
Hauptverfasser: Lesne, Jean, Locard-Paulet, Marie, Parra, Julien, Zivković, Dušan, Menneteau, Thomas, Bousquet, Marie-Pierre, Burlet-Schiltz, Odile, Marcoux, Julien
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7708635/
https://ncbi.nlm.nih.gov/pubmed/33262340
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-19934-z
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