Prophages are associated with extensive CRISPR–Cas auto-immunity

CRISPR–Cas systems require discriminating self from non-self DNA during adaptation and interference. Yet, multiple cases have been reported of bacteria containing self-targeting spacers (STS), i.e. CRISPR spacers targeting protospacers on the same genome. STS has been suggested to reflect potential...

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Bibliographic Details
Published in:Nucleic Acids Res
Main Authors: Nobrega, Franklin L, Walinga, Hielke, Dutilh, Bas E, Brouns, Stan J J
Format: Artigo
Language:Inglês
Published: Oxford University Press 2020
Subjects:
Data Resources and Analyses
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7708048/
https://ncbi.nlm.nih.gov/pubmed/33219687
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkaa1071
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