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Glutamine metabolism modulates azole susceptibility in Trypanosoma cruzi amastigotes

The mechanisms underlying resistance of the Chagas disease parasite, Trypanosoma cruzi, to current therapies are not well understood, including the role of metabolic heterogeneity. We found that limiting exogenous glutamine protects actively dividing amastigotes from ergosterol biosynthesis inhibito...

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Pubblicato in:eLife
Autori principali: Dumoulin, Peter C, Vollrath, Joshua, Tomko, Sheena Shah, Wang, Jennifer X, Burleigh, Barbara
Natura: Artigo
Lingua:Inglês
Pubblicazione: eLife Sciences Publications, Ltd 2020
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7707839/
https://ncbi.nlm.nih.gov/pubmed/33258448
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.60226
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