Loss of RIPK3 and Caspase-8 Augments Intrinsic Apoptosis in Tubular Epithelial Cell and promote Kidney Ischemia Reperfusion Injury

BACKGROUND: Ischemia reperfusion injury (IRI) is associated with programmed cell death that promotes inflammation and organ dysfunction. Necroptosis is mediated by members of receptor interacting protein kinases (RIPK1/3). Inhibition of RIPK1/3 provides a pro-survival benefit in kidney IRI. Caspase-...

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Publicado en:Nephrology (Carlton)
Main Authors: Sung, Baekjun, Su, Ye, Jiang, Jifu, Mcleod, Patrick, Liu, Weihua, Haig, Aaron, Green, Douglas R., Zhang, Zhu-Xu, Jevnikar, Anthony M.
Formato: Artigo
Idioma:Inglês
Publicado: 2019
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7706480/
https://ncbi.nlm.nih.gov/pubmed/30175514
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/nep.13487
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