The solution structure of the complement deregulator FHR5 reveals a compact dimer and provides new insights into CFHR5 nephropathy

The human complement Factor H–related 5 protein (FHR5) antagonizes the main circulating complement regulator Factor H, resulting in the deregulation of complement activation. FHR5 normally contains nine short complement regulator (SCR) domains, but a FHR5 mutant has been identified with a duplicated...

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Bibliographische Detailangaben
Veröffentlicht in:J Biol Chem
Hauptverfasser: Kadkhodayi-Kholghi, Nilufar, Bhatt, Jayesh S., Gor, Jayesh, McDermott, Lindsay C., Gale, Daniel P., Perkins, Stephen J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2020
Schlagworte:
Immunology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7705313/
https://ncbi.nlm.nih.gov/pubmed/32928961
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.015132
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