Neonatal microglia-organized scar-free spinal cord repair

It is thought that spinal cord injury triggers scar formation with little axon regeneration in mammals(1–4). Here we report that in neonatal mice, a crush injury to the spinal cord leads to a scar-free healing that permits the growth of long projecting axons through the lesion. Depletion of microgli...

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Gepubliceerd in:Nature
Hoofdauteurs: Li, Yi, He, Xuelian, Kawaguchi, Riki, Zhang, Yu, Wang, Qing, Monavarfeshani, Aboozar, Yang, Zhiyun, Chen, Bo, Shi, Zhongju, Meng, Huyan, Zhou, Songlin, Zhu, Junjie, Jacobi, Anne, Swarup, Vivek, Popovich, Phillip G., Geschwind, Daniel H, He, Zhigang
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2020
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7704837/
https://ncbi.nlm.nih.gov/pubmed/33029008
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-020-2795-6
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