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Adenylate Kinase 4 Modulates the Resistance of Breast Cancer Cells to Tamoxifen through an m(6)A-Based Epitranscriptomic Mechanism

N(6)-methyladenosine (m(6)A) is the most abundant internal modification in mRNA and this methylation constitutes an important regulatory mechanism for the stability and translational efficiency of mRNA. In this study, we found that the protein levels of adenylate kinase 4 (AK4) and m(6)A writer METT...

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Publicat a:Mol Ther
Autors principals: Liu, Xiaochuan, Gonzalez, Gwendolyn, Dai, Xiaoxia, Miao, Weili, Yuan, Jun, Huang, Ming, Bade, David, Li, Lin, Sun, Yuxiang, Wang, Yinsheng
Format: Artigo
Idioma:Inglês
Publicat: American Society of Gene & Cell Therapy 2020
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7704734/
https://ncbi.nlm.nih.gov/pubmed/32956623
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymthe.2020.09.007
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