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Using modern approaches to sedimentation velocity to detect conformational changes in proteins

It has been known for decades that proteins undergo conformational changes in response to binding ligands. Such changes are usually accompanied by a loss of entropy by the protein, and thus conformational changes are integral to the thermodynamics of ligand association. Methods to detect these alter...

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Detalles Bibliográficos
Publicado en:Eur Biophys J
Main Authors: Brautigam, Chad A., Tso, Shih-Chia, Deka, Ranjit K., Liu, Wei Z., Norgard, Michael V.
Formato: Artigo
Idioma:Inglês
Publicado: 2020
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7704540/
https://ncbi.nlm.nih.gov/pubmed/32761255
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00249-020-01453-w
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