The Wnt-β-catenin-IL-10 signaling axis in intestinal antigen-presenting cells protects mice from colitis-associated colon cancer in response to gut microbiota

Loss of immune tolerance to gut microflora is inextricably linked to chronic intestinal inflammation and colitis-associated colon cancer (CAC). The LRP5/6 signaling cascade in antigen-presenting cells (APCs) contributes to immune homeostasis in the gut but whether this pathway in APCs protects again...

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Detalhes bibliográficos
Publicado no:J Immunol
Main Authors: Swafford, Daniel, Shanmugam, Arulkumaran, Ranganathan, Punithavathi, Manoharan, Indumathi, Hussein, Mohamed S, Patel, Nikhil, Sifuentes, Humberto, Koni, Pandelakis A, Prasad, Puttur D, Thangaraju, Muthusamy, Manicassamy, Santhakumar
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7702805/
https://ncbi.nlm.nih.gov/pubmed/32917787
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1901376
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