Elucidating Epigenetic Regulation by Identifying Functional cis‐Acting Long Noncoding RNAs and Their Targets in Osteoarthritic Articular Cartilage

OBJECTIVE: To identify robustly differentially expressed long noncoding RNAs (lncRNAs) with osteoarthritis (OA) pathophysiology in cartilage and to explore potential target messenger RNA (mRNA) by establishing coexpression networks, followed by functional validation. METHODS: RNA sequencing was perf...

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Bibliografiske detaljer
Udgivet i:Arthritis Rheumatol
Main Authors: van Hoolwerff, Marcella, Metselaar, Paula I., Tuerlings, Margo, Suchiman, H. Eka D., Lakenberg, Nico, Ramos, Yolande F.M., Cats, Davy, Nelissen, Rob G.H.H., Broekhuis, Demiën, Mei, Hailiang, de Almeida, Rodrigo Coutinho, Meulenbelt, Ingrid
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2020
Fag:
Osteoarthritis
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7702083/
https://ncbi.nlm.nih.gov/pubmed/32840049
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.41396
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