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The Role of Cholesterol on Triterpenoid Saponin-Induced Endolysosomal Escape of a Saporin-Based Immunotoxin

Cholesterol seems to play a central role in the augmentation of saporin-based immunotoxin (IT) cytotoxicity by triterpenoid saponins. Endolysosomal escape has been proposed as one mechanism for the saponin-mediated enhancement of targeted toxins. We investigated the effects of lipid depletion follow...

詳細記述

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書誌詳細
出版年:Int J Mol Sci
主要な著者: Smith, Wendy S., Johnston, David A., Wensley, Harrison J., Holmes, Suzanne E., Flavell, Sopsamorn U., Flavell, David J.
フォーマット: Artigo
言語:Inglês
出版事項: MDPI 2020
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC7699356/
https://ncbi.nlm.nih.gov/pubmed/33228031
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21228734
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