The Role of Structure and Biophysical Properties in the Pleiotropic Effects of Statins

Statins are a class of drugs used to lower low-density lipoprotein cholesterol and are amongst the most prescribed medications worldwide. Most statins work as a competitive inhibitor of 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase (HMGR), but statin intolerance from pleiotropic effects have been...

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Bibliographic Details
Published in:Int J Mol Sci
Main Authors: Murphy, Christopher, Deplazes, Evelyne, Cranfield, Charles G., Garcia, Alvaro
Format: Artigo
Language:Inglês
Published: MDPI 2020
Subjects:
Review
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7699354/
https://ncbi.nlm.nih.gov/pubmed/33228116
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21228745
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