A Novel Purification Procedure for Active Recombinant Human DPP4 and the Inability of DPP4 to Bind SARS-CoV-2

Proteases catalyse irreversible posttranslational modifications that often alter a biological function of the substrate. The protease dipeptidyl peptidase 4 (DPP4) is a pharmacological target in type 2 diabetes therapy primarily because it inactivates glucagon-like protein-1. DPP4 also has roles in...

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Publicado en:Molecules
Main Authors: Xi, Cecy R, Di Fazio, Arianna, Nadvi, Naveed Ahmed, Patel, Karishma, Xiang, Michelle Sui Wen, Zhang, Hui Emma, Deshpande, Chandrika, Low, Jason K K, Wang, Xiaonan Trixie, Chen, Yiqian, McMillan, Christopher L D, Isaacs, Ariel, Osborne, Brenna, Vieira de Ribeiro, Ana Júlia, McCaughan, Geoffrey W, Mackay, Joel P, Church, W Bret, Gorrell, Mark D
Formato: Artigo
Idioma:Inglês
Publicado: MDPI 2020
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7698748/
https://ncbi.nlm.nih.gov/pubmed/33218025
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules25225392
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