Integrity of the Antiviral STING-mediated DNA Sensing in Tumor Cells Is Required to Sustain the Immunotherapeutic Efficacy of Herpes Simplex Oncolytic Virus

SIMPLE SUMMARY: Oncolytic viruses are emerging immunotherapeutics in cancer treatments. The conflicting role of innate immunity in the antitumor activity of oncolytic viruses is still a matter of debate. The STING-dependent DNA sensing axis is considered detrimental for viral replication and cancer...

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Veröffentlicht in:Cancers (Basel)
Hauptverfasser: Froechlich, Guendalina, Caiazza, Carmen, Gentile, Chiara, D’Alise, Anna Morena, De Lucia, Maria, Langone, Francesca, Leoni, Guido, Cotugno, Gabriella, Scisciola, Vittorio, Nicosia, Alfredo, Scarselli, Elisa, Mallardo, Massimo, Sasso, Emanuele, Zambrano, Nicola
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7698602/
https://ncbi.nlm.nih.gov/pubmed/33213060
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers12113407
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