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Comprehensive Set of Tertiary Complex Structures and Palmitic Acid Binding Provide Molecular Insights into Ligand Design for RXR Isoforms

The retinoid X receptor (RXR) is a ligand-sensing transcription factor acting mainly as a universal heterodimer partner for other nuclear receptors. Despite presenting as a potential therapeutic target for cancer and neurodegeneration, adverse effects typically observed for RXR agonists, likely due...

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Bibliografiske detaljer
Udgivet i:Int J Mol Sci
Main Authors: Chaikuad, Apirat, Pollinger, Julius, Rühl, Michael, Ni, Xiaomin, Kilu, Whitney, Heering, Jan, Merk, Daniel
Format: Artigo
Sprog:Inglês
Udgivet: MDPI 2020
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7697888/
https://ncbi.nlm.nih.gov/pubmed/33187070
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21228457
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