Molecular Mechanisms of Resistance to FLT3 Inhibitors in Acute Myeloid Leukemia: Ongoing Challenges and Future Treatments

Treatment of FMS-like tyrosine kinase 3 (FLT3)-internal tandem duplication (ITD)-positive acute myeloid leukemia (AML) remains a challenge despite the development of novel FLT3-directed tyrosine kinase inhibitors (TKI); the relapse rate is still high even after allogeneic stem cell transplantation....

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Udgivet i:Cells
Main Authors: Scholl, Sebastian, Fleischmann, Maximilian, Schnetzke, Ulf, Heidel, Florian H.
Format: Artigo
Sprog:Inglês
Udgivet: MDPI 2020
Fag:
Review
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7697863/
https://ncbi.nlm.nih.gov/pubmed/33212779
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cells9112493
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