The Rationale for Angiotensin Receptor Neprilysin Inhibitors in a Multi-Targeted Therapeutic Approach to COVID-19

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) disease (COVID-19) determines the angiotensin converting enzyme 2 (ACE2) down-regulation and related decrease in angiotensin II degradation. Both these events trigger “cytokine storm” leading to acute lung and cardiovascular injury. A...

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Bibliografiske detaljer
Udgivet i:Int J Mol Sci
Main Authors: Bellis, Alessandro, Mauro, Ciro, Barbato, Emanuele, Trimarco, Bruno, Morisco, Carmine
Format: Artigo
Sprog:Inglês
Udgivet: MDPI 2020
Fag:
Review
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7696732/
https://ncbi.nlm.nih.gov/pubmed/33203141
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21228612
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