Sirtuin 6 deficiency induces endothelial cell senescence via downregulation of forkhead box M1 expression

Cellular senescence of endothelial cells causes vascular dysfunction, promotes atherosclerosis, and contributes to the development of age-related vascular diseases. Sirtuin 6 (SIRT6), a conserved NAD+-dependent protein deacetylase, has beneficial effects against aging, despite the fact that its func...

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Vydáno v:Aging (Albany NY)
Hlavní autoři: Lee, Ok-Hee, Woo, Yun Mi, Moon, Sohyeon, Lee, Jihyun, Park, Haeun, Jang, Hoon, Park, Yun-Yong, Bae, Soo-Kyung, Park, Keun-Hong, Heo, Ji Hoe, Choi, Youngsok
Médium: Artigo
Jazyk:Inglês
Vydáno: Impact Journals 2020
Témata:
Priority Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7695388/
https://ncbi.nlm.nih.gov/pubmed/33171439
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/aging.202176
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