Neuroprotective epi-drugs quench the inflammatory response and microglial/macrophage activation in a mouse model of permanent brain ischemia

BACKGROUND: Activation of NF-kappaB RelA deacetylated at the lysine residues, except the lysine 310, drives pro-apoptotic transcription in noxious brain ischemia. We showed that the sinergistic combination of the histone deacetilase inhibitor MS-275 with the sirtuin 1 activator resveratrol, at very...

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Publicado en:J Neuroinflammation
Main Authors: Mota, Mariana, Porrini, Vanessa, Parrella, Edoardo, Benarese, Marina, Bellucci, Arianna, Rhein, Sina, Schwaninger, Markus, Pizzi, Marina
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2020
Assuntos:
Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7694916/
https://ncbi.nlm.nih.gov/pubmed/33246465
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-020-02028-4
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