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Binding of κ-Conotoxin-PVIIA to Open and Closed Shaker K-Channels Are Differentially Affected by the Ionic Strength

κ-Conotoxin-PVIIA (κ-PVIIA) is a potassium-channel blocking peptide from the venom of the fish-hunting snail, Conus purpurascens, which is essential for quick prey’s excitotoxic immobilization. Binding of one κ-PVIIA to Shaker K-channels occludes the K(+)-conduction pore without additional conformat...

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Bibliografski detalji
Izdano u:Mar Drugs
Glavni autori: Naranjo, David, Díaz-Franulic, Ignacio
Format: Artigo
Jezik:Inglês
Izdano: MDPI 2020
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7694074/
https://ncbi.nlm.nih.gov/pubmed/33114777
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/md18110533
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