Concerted cell and in vivo screen for pancreatic ductal adenocarcinoma (PDA) chemotherapeutics

PDA is a major cause of US cancer-related deaths. Oncogenic Kras presents in 90% of human PDAs. Kras mutations occur early in pre-neoplastic lesions but are insufficient to cause PDA. Other contributing factors early in disease progression include chronic pancreatitis, alterations in epigenetic regu...

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Pubblicato in:Sci Rep
Autori principali: Layeghi-Ghalehsoukhteh, Somayeh, Pal Choudhuri, Shreoshi, Ocal, Ozhan, Zolghadri, Yalda, Pashkov, Victor, Niederstrasser, Hanspeter, Posner, Bruce A., Kantheti, Havish S., Azevedo-Pouly, Ana C., Huang, Huocong, Girard, Luc, MacDonald, Raymond J., Brekken, Rolf A., Wilkie, Thomas M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7693321/
https://ncbi.nlm.nih.gov/pubmed/33244070
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-77373-8
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