Chemical hypoxia induces apoptosis of human pluripotent stem cells by a NOXA-mediated HIF-1α and HIF-2α independent mechanism

Human embryonic and induced pluripotent stem cells (hESCs and hiPSCs) are self-renewing human pluripotent stem cells (hPSCs) that can differentiate to a wide range of specialized cells. Notably, hPSCs enhance their undifferentiated state and self-renewal properties in hypoxia (5% O(2)). Although tho...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Isaja, Luciana, Mucci, Sofía, Vera, Jonathan, Rodríguez-Varela, María Soledad, Marazita, Mariela, Morris-Hanon, Olivia, Videla-Richardson, Guillermo Agustín, Sevlever, Gustavo Emilio, Scassa, María Elida, Romorini, Leonardo
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7692563/
https://ncbi.nlm.nih.gov/pubmed/33244167
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-77792-7
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