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Mechanistic insight on the remdesivir binding to RNA-Dependent RNA polymerase (RdRp) of SARS-cov-2

The RNA-dependent RNA polymerase (RdRp) is a key enzyme which regulates the viral replication of SARS-CoV-2. Remdesivir (RDV) is clinically used drug which targets RdRp, however its mechanism of action remains elusive. This study aims to find out the binding dynamics of active Remdesivir-triphosphat...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Comput Biol Med
Prif Awduron: Arba, Muhammad, Wahyudi, Setyanto Tri, Brunt, Dylan J., Paradis, Nicholas, Wu, Chun
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Elsevier Ltd. 2021
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7691827/
https://ncbi.nlm.nih.gov/pubmed/33260103
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.compbiomed.2020.104156
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