RasV12 Expression in Microglia Initiates Retinal Inflammation and Induces Photoreceptor Degeneration

PURPOSE: The role of activated retinal microglia in driving retinal degeneration has been implicated in a number of in vivo disease models. Here, we investigated the primary consequences of microglial activation by the specific expression of constitutively active Ras in microglia in a transgenic mou...

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Udgivet i:Invest Ophthalmol Vis Sci
Main Authors: Moriuchi, Yuta, Iwagawa, Toshiro, Tsuhako, Asano, Koso, Hideto, Fujita, Yasuyuki, Watanabe, Sumiko
Format: Artigo
Sprog:Inglês
Udgivet: The Association for Research in Vision and Ophthalmology 2020
Fag:
Retina
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7691791/
https://ncbi.nlm.nih.gov/pubmed/33231622
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.61.13.34
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