Inhibition of copper transporter 1 prevents α-synuclein pathology and alleviates nigrostriatal degeneration in AAV-based mouse model of Parkinson's disease

The formation of α-synuclein aggregates is a major pathological hallmark of Parkinson's disease. Copper promotes α-synuclein aggregation and toxicity in vitro. The level of copper and copper transporter 1, which is the only known high-affinity copper importer in the brain, decreases in the subs...

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Bibliographic Details
Published in:Redox Biol
Main Authors: Gou, De-Hai, Huang, Ting-Ting, Li, Wen, Gao, Xin-Di, Haikal, Caroline, Wang, Xin-He, Song, Dong-Yan, Liang, Xin, Zhu, Lin, Tang, Yong, Ding, Chen, Li, Jia-Yi
Format: Artigo
Language:Inglês
Published: Elsevier 2020
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Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7691620/
https://ncbi.nlm.nih.gov/pubmed/33232911
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.redox.2020.101795
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