Cerebellar and hepatic alterations in ACBD5-deficient mice are associated with unexpected, distinct alterations in cellular lipid homeostasis

ACBD5 deficiency is a novel peroxisome disorder with a largely uncharacterized pathology. ACBD5 was recently identified in a tethering complex mediating membrane contacts between peroxisomes and the endoplasmic reticulum (ER). An ACBD5-deficient mouse was analyzed to correlate ACBD5 tethering functi...

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Pubblicato in:Commun Biol
Autori principali: Darwisch, Warda, von Spangenberg, Marino, Lehmann, Jana, Singin, Öznur, Deubert, Geralt, Kühl, Sandra, Roos, Johannes, Horstmann, Heinz, Körber, Christoph, Hoppe, Simone, Zheng, Hongwei, Kuner, Thomas, Pras-Raves, Mia L., van Kampen, Antoine H. C., Waterham, Hans R., Schwarz, Kathrin V., Okun, Jürgen G., Schultz, Christian, Vaz, Frédéric M., Islinger, Markus
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7691522/
https://ncbi.nlm.nih.gov/pubmed/33244184
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42003-020-01442-x
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