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Fibrinolysis-resistant carbonylated fibrin detected in thrombi attached to the vascular wall of abdominal aortic aneurysms

In this study, we investigated how carbonylation of fibrinogen by acrolein modified its indispensable function to enhance fibrinolysis after being converted to fibrin and contributed to generating a fibrinolysis-resistant fibrin clot. Acrolein-treated fibrinogen was subjected to tissue plasminogen a...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Suzuki, Yuko, Tanaka, Hiroki, Horinouchi, Takahiro, Sano, Hideto, Honkura, Naoki, Unno, Naoki, Miwa, Soichi, Urano, Tetsumei
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7691368/
https://ncbi.nlm.nih.gov/pubmed/33244022
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-77582-1
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